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- Title
Assessing genetic architecture and signatures of selection of dual purpose Gir cattle populations using genomic information.
- Authors
Maiorano, Amanda Marchi; Lourenco, Daniela Lino; Tsuruta, Shogo; Ospina, Alejandra Maria Toro; Stafuzza, Nedenia Bonvino; Masuda, Yutaka; Filho, Anibal Eugenio Vercesi; Cyrillo, Joslaine Noely dos Santos Goncalves; Curi, Rogério Abdallah; Silva, Josineudson Augusto II de Vasconcelos
- Abstract
Gir is one of the main cattle breeds raised in tropical South American countries. Strong artificial selection through its domestication resulted in increased genetic differentiation among the countries in recent years. Over the years, genomic studies in Gir have become more common. However, studies of population structure and signatures of selection in divergent Gir populations are scarce and need more attention to better understand genetic differentiation, gene flow, and genetic distance. Genotypes of 173 animals selected for growth traits and 273 animals selected for milk production were used in this study. Clear genetic differentiation between beef and dairy populations was observed. Different criteria led to genetic divergence and genetic differences in allele frequencies between the two populations. Gene segregation in each population was forced by artificial selection, promoting isolation, and increasing genetic variation between them. Results showed evidence of selective forces in different regions of the genome. A total of 282 genes were detected under selection in the test population based on the fixation index (Fst), integrated haplotype score (iHS), and cross-population extend haplotype homozygosity (XP-EHH) approaches. The QTL mapping identified 35 genes associated with reproduction, milk composition, growth, meat and carcass, health, or body conformation traits. The investigation of genes and pathways showed that quantitative traits associated to fertility, milk production, beef quality, and growth were involved in the process of differentiation of these populations. These results would support further investigations of population structure and differentiation in the Gir breed.
- Subjects
CATTLE breeding; CATTLE breeds; CATTLE population genetics; GENETIC polymorphisms; ANIMAL genetics; CATTLE
- Publication
PLoS ONE, 2018, Vol 13, Issue 8, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0200694