We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Efficacy of Leviteracetam versus Carbamazepine for Epilepsy: A Meta-Analysis.
- Authors
Zhaoxia LI; Zhuanglei GAO; Chengjuan JIN; Qinghui GUO; Lihua WANG; Shandan WANG; Xue ZHANG; Yayun WANG
- Abstract
Leviteracetam (LEV) is a novel antiepileptic drug with improved tolerance and safety, while carbamazepine (CBZ) represents classical antiepileptic drugs. So far, a systemic comparison of the efficacy and side effects of these two drugs is lacking. A literature review on the comparison of leviteracetam versus carbamazepine for patients with epilepsy was performed up to September 2013 using PubMed, EMBASE, the Cochrane Library and ISI web of science. Finally, 3 randomized controlled trials (RCT) studies met the criteria on comparing the efficacy of leviteracetam versus carbamazepine for patients with epilepsy were included for meta-analysis. Stata 11.0 was used to analyze and summarize the respective data. Three RCTs met the entry criteria. The relative risk (RR) and 95% and the confidence interval (CI) of leviteracetam versus carbamazepine for 6- and 12-month seizure free intervals were 1.0 (0.91-1.10) and 0.97 (0.84- 1.13), respectively, for therapy discontinuation due to adverse events (AEs) were 0.62 (0.48-0.80) and 1.00 (0.94-2.05), respectively, and for withdrawal after 6- and 12-month treatment were 0.8 (0.64-0.99) and 0.87 (0.74-1.03), respectively. The RR and 95% CI for occurrence of headache, fatigue, diarrhea, vertigo, nasopharyngitis, depression, weight gain and rash were 0.88 (0.73-1.06), 1.08(0.63-1.83), 1.23 (0.66-2.28), 0.92 (0.49-1.71), 0.85 (0.59-1.22), 2.15 (1.26-3.68), 0.69 (0.45-1.04), 0.39 (0.23-0.68), respectively. The major outcomes such as rate of seizure freedom were similar between leviteracetam and carbamazepine. However, leviteracetam led to depression more frequently than carbamazepine, while carbamazepine caused rash more frequently. However, the limited numbers of available RCTs studies and included patients in this study made our results less convincing and accurate.
- Subjects
MENTAL depression risk factors; CARBAMAZEPINE; EXANTHEMA; ANTICOAGULANTS; ANTICONVULSANTS; COMPARATIVE studies; CONFIDENCE intervals; DATABASE evaluation; EPILEPSY; MEDICAL databases; INFORMATION storage &; retrieval systems; MEDICAL information storage &; retrieval systems; MEDLINE; META-analysis; ONLINE information services; RESEARCH evaluation; RESEARCH funding; SYSTEMATIC reviews; EVIDENCE-based medicine; PROFESSIONAL practice; TREATMENT effectiveness; DISEASE remission; PATIENT dropouts; TREATMENT duration; ODDS ratio; THERAPEUTICS; DISEASE risk factors
- Publication
Iranian Journal of Public Health, 2014, Vol 43, Issue 12, p1616
- ISSN
2251-6085
- Publication type
Article