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- Title
Effect of Vitamin E and Metformin on Fatty Liver Disease in Obese Children- Randomized Clinical Trial.
- Authors
SHIASI ARANI, Kobra; TAGHAVI ARDAKANI, Abbas; MOAZAMI GOUDARZI, Razieh; TALARI, Hamid reza; HAMI, Kamran; AKBARI, Hossein; AKBARI, Nima
- Abstract
Background: We evaluated the effect of vitamin E and metformin on fatty liver disease in obese children.Methods: This interventional study has been done on 119 children with Non-alcoholic fatty liver disease (based on sonography results). Patients were divided into four treatment groups; they received metformin 1gr daily (age< 12 years), metformin 1.5 gr daily (age> 12 years), vitamin E 800 U daily and vitamin E 400 U daily. Liver sonography was performed for patients for two periods of two months. This trial was registered in Iranian Registry of Clinical Trials (IRCT), No.IRCT2013021012421N1 Results: The study group comprised 119 individuals (62 females, 57 males). The mean age was 10± 3.19 yr. There was no significant difference in terms of sex and BMI between the groups. Overall liver sonography showed normal liver in 66 patients (55.46%), 66.63% after two months and 33.37% after four months. After two months, the most therapeutic response observed in the group which received vitamin E 800 u daily (48.1%) and the least therapeutic response was in the group which received vitamin E 400 u daily (14.3%). After four months, the greater response was seen in vitamin E 400 u daily group (45.8%) and the least response in the metformin 1 gram daily group (19%). Conclusion: In comparison with metformin, vitamin E is more influential in remission; however both are efficient in treatment of fatty liver. Vitamin E 400 u daily responses better in four-month treatment.
- Subjects
IRAN; THERAPEUTIC use of vitamin E; FATTY liver prevention; METFORMIN; BLOOD sugar monitoring; CHI-squared test; CLINICAL trials; COMPARATIVE studies; LIVER; LONGITUDINAL method; CHILDHOOD obesity; HEALTH outcome assessment; PHARMACEUTICAL arithmetic; RESEARCH funding; STATISTICAL sampling; STATISTICS; T-test (Statistics); TIME; DATA analysis; BODY mass index; RANDOMIZED controlled trials; TREATMENT effectiveness; REPEATED measures design; DISEASE remission; DESCRIPTIVE statistics
- Publication
Iranian Journal of Public Health, 2014, Vol 43, Issue 10, p1417
- ISSN
2251-6085
- Publication type
Article