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- Title
Morphological Study of Liver Disease in Alcoholics - an Autopsy Study.
- Authors
Yadav, J. K.; Jadhav, M. N.; Kittur, S. K.; Shetty, A.
- Abstract
Background and Objectives: Alcohol induced liver disease is a major cause of ill health and mortality. This autopsy study is conducted to know the morphological changes of liver disease in alcoholics and to study the incidental liver findings. Materials and Method: Present study is a prospective descriptive study. Total of 50 autopsy liver specimens with history of habitual alcohol intake, laboratory findings and autopsy findings were collected from the department of Forensic medicine during the period 2011-13. Detailed gross and microscopic examination of liver specimens were done. Results: Mean duration of alcohol consumption was 13years. Hepatomegaly was the common gross finding seen in 42%(n-21) of cases. Hepatic steatosis of macrovesicular type and severe grade was the common microscopic finding seen in 54%(n-27) of cases . Fibrosis was seen in 94%(n-47) cases and association between duration of alcohol consumption and fibrosis was statistically significant. Hepatic siderosis i.e. stainable iron was found in 70%(n-35) of cases and veno-occlusive lesion seen in all the cases. Miliary tuberculosis was the incidental finding seen in 8%(n-4) of cases. Conclusion: Autopsy is an excellent learning tool. This study showed that fibrosis and veno-occlusive lesions were invariable findings and on progression leads to cirrhosis which is an end stage liver disease.
- Subjects
LIVER diseases; DISEASES in people with alcoholism; AUTOPSY; HEPATOMEGALY; FIBROSIS
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2015, Vol 9, Issue 1, p219
- ISSN
0973-9122
- Publication type
Article
- DOI
10.5958/0973-9130.2015.00053.5