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- Title
Oculopalatal Tremor: Variations on a Theme by Guillain and Mollaret.
- Authors
Jang, Liuna; Borruat, François-Xavier
- Abstract
Background: Oculopalatal tremor (OPT) is a delayed complication of a brainstem lesion, characterized by involuntary contractions of the soft palate associated with a synchronized ocular pendular nystagmus. MRI reveals inferior olivary nucleus hypersignal/hypertrophy (IONH). Our objective was to refine the clinical profile of patients with OPT and to report a few oddities in both presentation and evolution. Methods: We performed a retrospective study of patients diagnosed with OPT and a literature search. Results: From our database, we retrieved 5 men and 3 women with a diagnosis of OPT. Eighty-two patients with OPT were retrieved from the literature and were compiled with our series. The average age was 54 years and there was a male predominance. Brainstem vascular lesion was the most common etiology (80%). Prominent vertical pendular nystagmus was found in 90%. Dissociated nystagmus was mostly associated to unilateral contralateral IONH on MRI, while bilateral symmetrical nystagmus was due to a bilateral IONH in the majority of cases. Three oddities were found amongst our 8 patients: prominent nystagmus ipsilateral to IONH; disappearance of IONH on MRI despite persisting nystagmus, and asymptomatic OPT. Conclusion: The clinical profile of OPT is rather stereotyped. Rarely do patients deviate from the classical description of OPT. © 2014 S. Karger AG, Basel
- Subjects
TREMOR; MOVEMENT disorders; NYSTAGMUS; HYPERTROPHY; OLIVARY nucleus; DIAGNOSIS
- Publication
European Neurology, 2014, Vol 72, Issue 3/4, p144
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000360531