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- Title
A Simple and Cost-Effective Method for the Regioselective Deuteration of Phenols.
- Authors
Miao Zhan; Ruixue Xu; Ye Tian; Hongxia Jiang; Lifeng Zhao; Yongmei Xie; Yuanwei Chen
- Abstract
A highly effective and operationally simple method for the deuteration of phenols using NaOH as a catalyst and D2O as the deuterium source is presented. A high regioselectivity for the ortho and/or para hydrogens relative to the oxygen atom was achieved, as well as a high degree of deuterium incorporation. The method also has a high functional-group tolerance, and allowed the deuteration of complex pharmaceutically interesting substrates.
- Subjects
DEUTERATION; PHENOLS; CATALYSTS; HYDROGEN; OXYGEN
- Publication
European Journal of Organic Chemistry, 2015, p3370
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201500192