We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Gene4MND: An Integrative Genetic Database and Analytic Platform for Motor Neuron Disease.
- Authors
Zhao, Guihu; Liu, Zhen; Wang, Mengli; Yuan, Yanchun; Ni, Jie; Li, Wanzhen; Huang, Ling; Hu, Yiting; Liu, Pan; Hou, Xiaorong; Guo, Jifeng; Jiang, Hong; Shen, Lu; Tang, Beisha; Li, Jinchen; Wang, Junling
- Abstract
Functional Analysis Based on the Prioritized Genes Further data mining based on the prioritized genes was performed to schematize the functional relevance of MND-related genes, and genes with a total score of at least 4 were considered prioritized genes. For example, using GO analysis, we revealed that most MND-related genes are involved in the immune response, which is consistent with previous studies (Mantovani et al., [16]; Hooten et al., [11]; Brown and Al-Chalabi, [3]), suggesting that immunomodulation plays important roles in the pathogenesis of MND. Keywords: amyotrophic lateral sclerosis; motor neuron disease; one-stop online database; gene ontology analysis; immunomodulation; gene EN amyotrophic lateral sclerosis motor neuron disease one-stop online database gene ontology analysis immunomodulation gene N.PAG N.PAG 6 04/26/21 20210401 NES 210401 Introduction Motor neuron diseases (MND) refer to a wide and heterogeneous expanding group of neurodegenerative disorders involving the upper and lower motor neurons, which are characterized by rapidly progressive weakness leading to paralysis and eventually death from respiratory failure. In this study, we developed a one-stop database of MND-related genes and variants, Gene4MND, to facilitate analysis of genes and variants related to MND.
- Subjects
GENETIC databases; MOTOR neuron diseases; SPINAL muscular atrophy; AMYOTROPHIC lateral sclerosis; FRONTOTEMPORAL lobar degeneration; FAMILIAL spastic paraplegia; GENETIC epidemiology
- Publication
Frontiers in Molecular Neuroscience, 2021, Vol 13, pN.PAG
- ISSN
1662-5099
- Publication type
Article
- DOI
10.3389/fnmol.2021.644202