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- Title
Imipramine reverses the depressive symptoms in sepsis survivor rats.
- Authors
Tuon, Lisiane; Comim, Clarissa M.; Antunes, Moises M.; Constantino, Larissa S.; Machado, Roberta A.; Izquierdo, Ivan; Quevedo, João; Dal-Pizzol, Felipe; Quevedo, João
- Abstract
<bold>Objective: </bold>To evaluate the antidepressant effect of imipramine on depressive symptoms observed in sepsis survivors rats.<bold>Design and Setting: </bold>Prospective, controlled experiment in an animal basic science laboratory.<bold>Subjects: </bold>Male Wistar rats weighing 300-350 g.<bold>Interventions: </bold>The rats underwent cecal ligation and perforation (CLP; sepsis group) with "basic support" (saline at 50 ml/kg immediately and 12 h after CLP plus ceftriaxone at 30 mg/kg and clindamycin at 25 mg/kg 6, 12, and 18 h after CLP) or sham-operated (control group). After 10 days of recovery rats received intraperitoneal injections of imipramine 10 mg/kg or saline and were subjected to the forced swimming test.<bold>Measurements and Results: </bold>The observed increase in the immobility time in the forced swimming test in animals subjected to CLP, as a parameter of depressive behavior, was reversed by imipramine.<bold>Conclusions: </bold>The depressive symptoms evaluated by forced swimming test had been reversed after imipramine administration. Our data provide evidence that CLP-induced depressive symptoms are sensitive to antidepressants.
- Subjects
BRAZIL; LABORATORY rats; SEPSIS; ANTIBACTERIAL agents; DRUG administration; MENTAL depression; ANTIDEPRESSANTS; ANIMAL experimentation; COMPARATIVE studies; IMIPRAMINE; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; RATS; RESEARCH; EVALUATION research; TREATMENT effectiveness; PHARMACODYNAMICS; PSYCHOLOGY; THERAPEUTICS
- Publication
Intensive Care Medicine, 2007, Vol 33, Issue 12, p2165
- ISSN
0342-4642
- Publication type
journal article
- DOI
10.1007/s00134-007-0804-y