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- Title
Unique Rarity of Tuberculosis and Granulomatous Opportunistic Infections in Hematopoietic Cell Transplant Recipients.
- Authors
Singh, Nina
- Abstract
The article focuses on a major determinant for the control of Mycobacterium tuberculosis in the latent state is cellular immunity that is critically dependent on Th1 cytokines including interferon gamma, tumor necrosis factor alpha (TNF-α), and interleukin. It mentions that TNF-α is expressed in granulomatous tissue during the entire period of latency and serves to contain the infection in the nonreplicative phase; and Th2 response facilitates reactivation and disease progression.
- Subjects
TUBERCULOSIS risk factors; HEMATOPOIETIC stem cell transplantation; OPPORTUNISTIC infections; RARE diseases; RISK assessment; TRANSPLANTATION of organs, tissues, etc.; DISEASE risk factors
- Publication
Clinical Infectious Diseases, 2020, Vol 71, Issue 2, p470
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciz979