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- Title
Decreased Colorectal Adenoma Risk After Helicobacter pylori Eradication: A Retrospective Cohort Study.
- Authors
Hu, Kuang-Chun; Wu, Ming-Shiang; Chu, Cheng-Hsin; Wang, Horng-Yuan; Lin, Shee-Chan; Liu, Chuan-Chuan; Su, Tung-Hung; Liao, Wei-Chih; Chen, Chi-Ling; Liu, Chun-Jen; Shih, Shou-Chuan
- Abstract
Background Helicobacter pylori infection is associated with colorectal adenoma and confers a 1.3- to 2.26-fold increased risk. We evaluated the association between H. pylori and the progression of colorectal adenoma. Methods This retrospective cohort study included 615 adults with no history of colorectal adenoma or cancer at baseline who participated in a repeated, regular health screening examination, which included a bidirectional gastrointestinal endoscopy, between July 2006 and June 2015. A gastric biopsy specimen from each subject was tested for H. pylori. Results During follow-up, the incidence rates of colorectal adenoma progression in participants with persistent H. pylori infections (persistent group) and those whose infections had previously been successfully eradicated (eradication group) were 160.52 and 51.60 per 1000 person-years, respectively (P =.0003). After adjustment for confounding factors, the persistent group exhibited a higher risk of colorectal adenoma than the eradication group (hazard ratio = 3.04, 95% CI 1.899, 5.864). The colorectal adenoma ratio of patients uninfected with H. pylori was similar to that of the eradication group (23.93% vs 20.12%, P =.328). Conclusions Persistent H. pylori infection was associated significantly with the independent development of colorectal adenoma. H. pylori infection may have a pathophysiological role in colorectal adenoma development and, after successful eradication of H. pylori, the colorectal adenoma ratio might decrease.
- Subjects
ADENOMA; RECTUM tumors; TUMOR prevention; ADENOMA prevention; COLON tumor prevention; COLON tumors; CONFIDENCE intervals; GASTROSCOPY; HELICOBACTER diseases; LONGITUDINAL method; MEDICAL screening; MATHEMATICAL variables; RETROSPECTIVE studies; DISEASE progression; DISEASE eradication; ODDS ratio; DISEASE complications; DIAGNOSIS; DISEASE risk factors; TUMOR risk factors; CANCER risk factors
- Publication
Clinical Infectious Diseases, 2019, Vol 68, Issue 12, p2105
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1093/cid/ciy591