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- Title
Soybean protein-derived peptide nutriment increases negative nitrogen balance in burn injury-induced inflammatory stress response in aged rats through the modulation of white blood cells and immune factors.
- Authors
Jian Zhang; Wenhui Li; Zhiwei Ying; Di Zhao; Guofu Yi; He Li; Xinqi Liu
- Abstract
Background: As an important nutrient, soybean protein-derived peptides (SPP) affect the immune function of animals. Objective: This study describes the effects of nutrient supplementation with SPP on the negative nitrogen balance in the burn injury-induced inflammatory response of aged rats. Design: Soybean protein isolate (SPI) was hydrolyzed to obtain SPP. A negative nitrogen-balance aged rat model and a major full-thickness 30% total body surface area (TBSA) burn-injury rat model were utilized. Results: The results show that SPP can increase the speed and ability of inflammatory stress by adjusting white blood cell counts. Soybean protein-derived peptides significantly increased serum immunoglobulin M (IgM), immunoglobulin G (IgG) and immunoglobulin A (IgA) levels; significantly decreased serum interleukin-1 beta (IL-β), tumor necrosis factor-alpha (TNF-α) and regulated upon activation normal T-cell expressed and secreted (RANTES) levels. These results give conclusive evidence that SPP has a significantly positive effect in improving the immune function on the condition of negative nitrogen balance with burn-injury, and reducing excessive inflammation. Conclusions: Nutrient supplementation of SPP can, therefore, be used as an adjuvant treatment to inhibit the development and severity of inflammatory reactions caused by burns, providing a novel therapy for the treat- ment and positive prognosis of burn patients.
- Subjects
NITROGEN metabolism; ANIMAL experimentation; BURNS &; scalds; DIETARY supplements; IMMUNOGLOBULINS; INFLAMMATION; INTERLEUKINS; LEUCOCYTES; NUTRITIONAL requirements; PEPTIDES; RATS; SOY proteins; TUMOR necrosis factors; OXIDATIVE stress; BODY surface area
- Publication
Food & Nutrition Research, 2020, Vol 64, p1
- ISSN
1654-6628
- Publication type
Article
- DOI
10.29219/fnr.v64.3677