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- Title
Synthesis and Chiral Separation of Some 4-thioflavones.
- Authors
Zaid, Mohammed El Amin; Belboukhari, Nasser; Sekkoum, Khaled; Ibtissam, Bousmaha; Enein, Hassan Y Aboul
- Abstract
A thionation reaction was performed on some chiral flavanones using Lawesson's reagent (LR) and leads to the formation of new chiral thiocarbonyl flavanes. LR in this thionation reaction with Hesperetin and Naringenin gives new flavan-4-thiones with yields ranged between 41 and 52%. Based on the Wittig reaction principle, LR is currently the most widely used reagent for this type of reaction. Enantiomeric separation by high-performance liquid chromatography methods was then set-up using three different polysaccharide-based chiral stationary phases (CSPs). Chiral separations were successfully accomplished with high resolution (1.22 ≤ Rs ≤ 5.23). The chiral discrimination mechanism(s) between the analytes under study, mobile phase, and the CSPs were discussed.
- Subjects
CHIRAL stationary phases; HIGH performance liquid chromatography; WITTIG reaction; SULFURATION; HYDROPHILIC interaction liquid chromatography
- Publication
Journal of Chromatographic Science, 2021, Vol 59, Issue 9, p856
- ISSN
0021-9665
- Publication type
Article
- DOI
10.1093/chromsci/bmab007