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- Title
Oligometastatic adenoid cystic carcinoma: Correlating tumor burden and time to treatment with outcomes.
- Authors
Tyan, Kevin; Bae, Ji Eun; Lorch, Jochen H.; Margalit, Danielle N.; Tishler, Roy B.; Huynh, Mai Anh; Jo, Vickie Y.; Haddad, Robert I.; Chau, Nicole G.; Hanna, Glenn J.; Schoenfeld, Jonathan D.
- Abstract
Background: There is limited information on the management and outcomes of oligometastases (OM) in adenoid cystic carcinoma (ACC). Methods: Retrospective study of 42 patients with metastatic ACC of the head and neck. Imaging studies were analyzed to identify patients with OM (1–5 lesions) at any point during follow‐up. Results: There was radiographic evidence of OM in 33/42 (79%) patients. Eighteen patients had OM when treated for metastases, with median overall survival (OS) of 36.0 versus 9.2 years for patients with polymetastases (6+ lesions, HR 0.38, 95%CI 0.14–0.89). Earlier locally ablative treatment, but not systemic treatment, of patients with OM predicted improved survival 3 years after metastasis (HR 0.15, 95%CI 0.02–0.63) and postponed systemic treatment by 80 more months (HR 0.22, 95%CI 0.07–0.71). Conclusions: There is a considerable population of ACC patients with detectable oligometastases, and early locally ablative treatment of oligometastases may be associated with improved outcomes.
- Subjects
ADENOID cystic carcinoma; TREATMENT effectiveness; HEAD &; neck cancer; OVERALL survival
- Publication
Head & Neck, 2022, Vol 44, Issue 3, p722
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26964