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- Title
Evolution of the radiographic appearance of the metaphyses over the first year of life in type V osteogenesis imperfecta: Clues to pathogenesis.
- Authors
Arundel, Paul; Offiah, Amaka; Bishop, Nicholas J.
- Abstract
We present the first report of the development of characteristic radiologic appearances of long bones during the first year of life in an infant with type V osteogenesis imperfecta (OI). We show the evolution of metaphyseal abnormalities from a rickets-like appearance to the classically described dense metaphyseal bands. These abnormalities suggest that the underlying defect in type V OI may involve a molecule common to both bone and cartilage that is involved in the regulation of growth plate development and metadiaphyseal ossification. Our findings provide new insights into skeletal development in type V OI and potentially yield useful clues to the identity of the defect underpinning the condition. © 2011 American Society for Bone and Mineral Research.
- Subjects
OSTEORADIOGRAPHY; MEDICAL radiography; BONE growth; RICKETS; PEDIATRIC radiology
- Publication
Journal of Bone & Mineral Research, 2011, Vol 26, Issue 4, p894
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1002/jbmr.258