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- Title
Elevated Serum Levels of IGF-1 Are Sufficient to Establish Normal Body Size and Skeletal Properties Even in the Absence of Tissue IGF-1.
- Authors
Elis, Sebastien; Courtland, Hayden-William; Yingjie Wu; Rosen, Clifford J.; Hui Sun; Jepsen, Karl J.; Majeska, Robert J.; Yakar, Shoshana
- Abstract
The article presents a study which determined the effects of insulin-like growth factor 1 (IGF-1) on body size and skeletal properties without tissue IGF-1. The results of the study showed that an increase of IGF-1 serum made up for the lack of locally-produced IGF-1 since deficits in the early skeletal structures of test mice in the early stages were restored to normal levels by adulthood. The study concluded that a maintenance with elevations of serum IGF-1 suffices to bring about normal body size and composition of the body of test mice.
- Subjects
SOMATOMEDIN; BODY size; SKELETON; SERUM; LABORATORY mice
- Publication
Journal of Bone & Mineral Research, 2010, Vol 25, Issue 6, p1257
- ISSN
0884-0431
- Publication type
Article
- DOI
10.1002/jbmr.20