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- Title
Patient-controlled analgesia with oxycodone in the treatment of postcraniotomy pain.
- Authors
Tanskanen, P.; Kyttä, J.; Randell, T.; Kyttä, J
- Abstract
<bold>Background: </bold>Moderate to severe pain occurs after craniotomy in 60% of patients. We evaluated the feasibility and safety of patient-controlled analgesia (PCA) with oxycodone in neurosurgical patients, and compared the efficacy of paracetamol with ketoprofen.<bold>Methods: </bold>In the study there were 45 patients, who received either paracetamol 1000 mg or ketoprofen 100 mg three times a day. Oxycodone-boluses 0.03 mg/kg were given by PCA-device maximally three times an hour, lock-out time 10 min. The amount of oxycodone used, pain scores and side-effects were recorded.<bold>Results: </bold>The ketoprofen group required less oxycodone than the paracetamol group (medians 37.1 mg vs 19.6 mg, P < 0.05). The VAS scores were comparable between the groups at the beginning of the study, during the first postoperative evening and the next morning, but the paracetamol group had a higher score at the conclusion of the study (P < 0.05). The patients in both groups were equally satisfied with the pain relief. There were no differences in side-effects between the groups.<bold>Conclusions: </bold>PCA with oxycodone is a suitable method for pain control after craniotomy. No progressive hypoventilation, desaturation or excessive sedation were encountered. Ketoprofen appeared to be more effective than paracetamol.
- Subjects
ANALGESIA; CRANIOTOMY; PAIN management; THERAPEUTIC use of narcotics; ACETAMINOPHEN; ANALGESICS; COMBINATION drug therapy; CLINICAL trials; COMPARATIVE studies; CONSCIOUSNESS; RESEARCH methodology; MEDICAL cooperation; NARCOTICS; NONSTEROIDAL anti-inflammatory agents; OXYGEN; PATIENT satisfaction; PATIENT-controlled analgesia; POSTOPERATIVE pain; RESEARCH; SAFETY; OXYCODONE; PILOT projects; EVALUATION research; PAIN measurement; HYPOVENTILATION; RANDOMIZED controlled trials; CARBOCYCLIC acids; NONOPIOID analgesics; THERAPEUTICS
- Publication
Acta Anaesthesiologica Scandinavica, 1999, Vol 43, Issue 1, p42
- ISSN
0001-5172
- Publication type
journal article
- DOI
10.1034/j.1399-6576.1999.430110.x