We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
The Effects of a Calcium-Fortified Lemon Drink on Bone Density and Bone Metabolism in Postmenopausal Women.
- Authors
Hiromi Ikeda; Tadayuki Iida; Masanori Hiramitsu; Takashi Inoue; Miki Okada; Kazuhiko Yoshikawa; Toshihiko Goto; Shizuka Shigematu; Masae Watanabe; Yoshio Kanbara; Saori Kita; Kazuya Kunimura; Toshihide Harada
- Abstract
Objective: The present study investigated the effectiveness of 6 months' continuous consumption of a calcium-fortified test drink containing lemon juice by postmenopausal women to clarify the effects on bone metabolism. Materials and Methods: Participants were recruited on a volunteer basis from welfare facilities and among individuals associated with such facilities. Forty-four women gave consent for participation and were enrolled. Among these women who were enrolled, data from 40 postmenopausal women were analyzed. The study was conducted from October 2014 to April 2015. Participants consumed one 200-ml serving of the test drink every day for 6 months. Physical characteristics and bone mineral density (BMD) were measured before the start of the study (pre-consumption) and after 3 and 6 months of consumption of the drink. Levels of bone metabolism markers were measured pre-consumption and after 1, 3, and 6 months of consumption. Participants were classified as either low- or high-BMD based on whether their BMD was < 70% or > 70%, respectively, of the young adult mean. Results: Regarding the BMD change ratio, an increase in BMD was shown in both the high-and low-BMD groups after 3 months of consumption. The increase in the high-BMD group was maintained until after 6 months of consumption. Compared to pre-consumption, TRACP-5b levels were significantly lower after I month of consumption in both the high- (p < 0.001) and low-BMD (p = 0.002) groups, after which levels did not significantly change. Compared to pre-consumption, while no significant changes were observed after 3 and 6 months of consumption in the low-BMD group, osteocalcin (OC) levels in the high-BMD group were significantly lower after 6 months of consumption (p = 0.019). Compared to pre-consumption, bone alkaline phosphatase (BAP) levels were significantly lower after 3 months of consumption in both the high- (p < 0.001) and low-BMD (p < 0.001) groups, after which levels did not change. Conclusion: Continuous consumption of a calcium-fortified test drink containing lemon juice by postmenopausal women should have a prophylactic effect on future osteoporosis development.
- Subjects
ENRICHED foods; ALKALINE phosphatase; CALCIUM; LEMON; METABOLISM; BONE density; POSTMENOPAUSE; OSTEOCALCIN
- Publication
International Medical Journal, 2017, Vol 24, Issue 3, p279
- ISSN
1341-2051
- Publication type
Article