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- Title
The prognostic value of the post-treatment serum CA 125 level in patients with advanced endometrial cancer.
- Authors
Muzykiewicz, Konrad P.; Iwanska, Ewa; Pniewska, Karolina W.; Janeczek, Maja; Nowak-Jastrzab, Malgorzata; Kalamacki, Andrzej; Karolewski, Kazimierz; Blecharz, Pawel
- Abstract
Objectives: The goal of this analysis was to assess the prognostic value of the post-treatment serum CA 125 level in each member of a group of advanced endometrial cancer (aEC) patients in comparison to other clinical and pathological parameters. Material and methods: Records of 266 patients treated at the Maria Skłodowska-Curie Memorial Cancer Centre and Institute of Oncology, Cracow Branch between the years 2006 and 2018 were included in the study. Follow-up ranged from 1 to 138 months. Progression free survival (PFS) and overall survival (OS) were set as the endpoints. The tests chi-squared, Fisher, log-rank, Mann-Whitney, Kruskal-Wallis and Cox proportional hazard ratio were used for statistical analyses. Results: In the analysed group, there was a significant association between an elevated serum CA 125 level following adjuvant treatment and shorter PFS and OS. After setting a cut-off value for CA 125 there was a statistically significant correlation between the marker and PFS and OS. Multivariate analysis indicated that the post-treatment serum CA 125 level is an independent prognostic factor of the course of aEC. Conclusions: The post-treatment serum CA 125 level correlates significantly with both PFS and OS in each patient with aEC. The marker is an independent prognostic factor in this group. A low post-treatment level of the marker is a strong indicator of good 5-year survival, with 82% of patients reaching 5-year OS.
- Subjects
PROGNOSTIC tests; ENDOMETRIAL cancer; CHI-squared test; KRUSKAL-Wallis Test; IMMUNOLOGICAL adjuvants
- Publication
Ginekologia Polska, 2024, Vol 95, Issue 6, p419
- ISSN
0017-0011
- Publication type
Article
- DOI
10.5603/gpl.96205