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- Title
Phosphorylation of Cofilin Regulates Extinction of Conditioned Aversive Memory via AMPAR Trafficking.
- Authors
Yue Wang; Qing Dong; Xu-Feng Xu; Xuan Feng; Jian Xin; Dong-Dong Wang; Hui Yu; Tian Tian; Zhe-Yu Chen
- Abstract
Actin dynamics provide an important mechanism for the modification of synaptic plasticity, which is regulated by the actin depolymerizing factor (ADF)/cofilin. However, the role of cofilin regulated actin dynamics in memory extinction process is still unclear. Here, we observed that extinction of conditioned taste aversive (CTA) memory led to temporally enhanced ADF/cofilin activity in the infralimbic cortex (IrL) of the rats. Moreover, temporally elevating ADF/cofilin activity in the IrL could accelerate CTA memory extinction by facilitating AMPAR synaptic surface recruitment, whereas inhibition of ADF/cofilin activity abolished AMPAR synaptic surface trafficking and impaired memory extinction. Finally, we observed that ADF/cofilin-regulated synaptic plasticity was not directly coupled to morphological changes of postsynaptic spines. These findings may help us understand the role of ADF/cofilin-regulated actin dynamics in memory extinction and suggest that appropriate manipulating ADF/cofilin activity might be a suitable way for therapeutic treatment of memory disorders.
- Subjects
PHOSPHORYLATION; BRAIN research; ACTIN; NEUROPLASTICITY; MEMORY; MEMORY disorders; PHYSIOLOGY; DISEASE risk factors
- Publication
Journal of Neuroscience, 2013, Vol 33, Issue 15, p6423
- ISSN
0270-6474
- Publication type
Article
- DOI
10.1523/JNEUROSCI.5107-12.2013