We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Hybrid Immunity to SARS-CoV-2 During Pregnancy Provides More Durable Infant Antibody Responses Compared to Natural Infection Alone.
- Authors
LaCourse, Sylvia M; Wetzler, Erica A; Aurelio, Morgan C; Escudero, Jaclyn N; Selke, Stacy S; Greninger, Alexander L; Goecker, Erin A; Barnes, Sarina R; Arnould, Isabel S; Pérez-Osorio, Ailyn C; Richardson, Barbra A; Kachikis, Alisa; Englund, Janet A; Drake, Alison L
- Abstract
Background Hybrid immunity (infection plus vaccination) may increase maternally derived SARS-CoV-2 antibody responses and durability versus infection alone. Methods Prospective cohort of pregnant participants with prior SARS-CoV-2 infection (anti-nucleocapsid IgG, RT-PCR, or antigen positive) and their infants had blood collected in pregnancy, at delivery/birth, and postpartum tested for anti-spike (anti-S) IgG and neutralizing antibodies (neutAb). Results Among 107 participants at enrollment, 40% were unvaccinated and 60% were vaccinated (received ≥1 dose); 102 had previous SARS-CoV-2 infection in pregnancy (median, 19 weeks' gestation); 5 were diagnosed just prior to pregnancy (median, 8 weeks). At delivery, fewer unvaccinated participants (87% anti-S IgG+, 86% neutAb) and their infants (86% anti-S IgG+, 75% neutAb) had anti-S IgG+ or neutAb compared to vaccinated participants and their infants (100%, P ≤.01 for all). By 3–6 months postpartum, 50% of infants of unvaccinated participants were anti-S IgG+ and 14% had neutAb, versus 100% among infants of vaccinated participants (all P <.01), with lower median antibody responses (anti-S IgG log10 1.95 vs 3.84 AU/mL, P <.01; neutAb log10 1:1.34 vs 1:3.20, P =.11). Conclusions In pregnant people with prior SARS-CoV-2, vaccination before delivery provided more durable maternally derived antibody responses than infection alone in infants through 6 months.
- Subjects
ANTIBODY formation; PREGNANT women; SARS-CoV-2; PREGNANCY; INFANTS
- Publication
Journal of Infectious Diseases, 2024, Vol 229, Issue 6, p1728
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/jiad592