We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Individual, Household, and Community Drivers of Dengue Virus Infection Risk in Kamphaeng Phet Province, Thailand.
- Authors
Santos, Gabriel Ribeiro dos; Buddhari, Darunee; Iamsirithaworn, Sopon; Khampaen, Direk; Ponlawat, Alongkot; Fansiri, Thanyalak; Farmer, Aaron; Fernandez, Stefan; Thomas, Stephen; Barraquer, Isabel Rodriguez; Srikiatkhachorn, Anon; Huang, Angkana T; Cummings, Derek A T; Endy, Timothy; Rothman, Alan L; Salje, Henrik; Anderson, Kathryn B; Ribeiro Dos Santos, Gabriel; Rodriguez Barraquer, Isabel
- Abstract
<bold>Background: </bold>Dengue virus (DENV) often circulates endemically. In such settings with high levels of transmission, it remains unclear whether there are risk factors that alter individual infection risk.<bold>Methods: </bold>We tested blood taken from individuals living in multigenerational households in Kamphaeng Phet province, Thailand for DENV antibodies (N = 2364, mean age 31 years). Seropositivity ranged from 45.4% among those 1-5 years old to 99.5% for those >30 years. Using spatially explicit catalytic models, we estimated that 11.8% of the susceptible population gets infected annually.<bold>Results: </bold>We found that 37.5% of the variance in seropositivity was explained by unmeasured household-level effects with only 4.2% explained by spatial differences between households. The serostatus of individuals from the same household remained significantly correlated even when separated by up to 15 years in age.<bold>Conclusions: </bold>These findings show that despite highly endemic transmission, persistent differences in infection risk exist across households, the reasons for which remain unclear.
- Publication
Journal of Infectious Diseases, 2022, Vol 226, Issue 8, p1348
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiac177