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- Title
Plasma Inflammatory Biomarkers Predict CD4+ T-cell Recovery and Viral Rebound in HIV-1 Infected Africans on Suppressive Antiretroviral Therapy.
- Authors
Kroeze, Stefanie; Rossouw, Theresa M; Steel, Helen C; Wit, Ferdinand W; Kityo, Cissy M; Siwale, Margaret; Akanmu, Sulaimon; Mandaliya, Kishor; Jager, Marleen De; Ondoa, Pascale; Reiss, Peter; Wit, Tobias F Rinke De; Kootstra, Neeltje A; Hamers, Raph L; De Jager, Marleen; Rinke De Wit, Tobias F
- Abstract
This multicountry prospective study investigated whether persistent systemic inflammation, measured by 8 plasma biomarkers, in HIV-1-infected Africans during suppressive antiretroviral therapy (ART) (viral load <50 copies/mL), was associated with CD4+ T-cell recovery and viral rebound (>1000 copies/mL) during long-term treatment. On-ART sCD14 and C-reactive protein concentrations were inversely associated with subsequent CD4+ T-cell counts. Risk of viral rebound was increased for participants with higher on-ART CXCL10 concentrations and reduced for those with a greater sCD163 decline during the first year of ART. Persistent systemic inflammation predicted CD4+ T-cell recovery and viral rebound, warranting further mechanistic research in relation to clinical outcomes.
- Subjects
SUB-Saharan Africa; AFRICA; ANTIRETROVIRAL agents; HIV; MEDICAL research; TREATMENT effectiveness; VIRAL load; ANTI-HIV agents; HIV infections; RESEARCH; INFLAMMATION; RESEARCH methodology; HIV seroconversion; EVALUATION research; COMPARATIVE studies; CD4 lymphocyte count; RESEARCH funding; T cells; LONGITUDINAL method
- Publication
Journal of Infectious Diseases, 2021, Vol 224, Issue 4, p673
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/jiaa787