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- Title
Oral lichenoid lesion in association with chemotherapy treatment for non-Hodgkin lymphoma or lichen planus? Review of the literature and report of two challenging cases.
- Authors
Marques, Letícia Côgo; de Medeiros Nunes da Silva, Laiza Angela; Santos, Pâmella de Pinho Montovani; de Almeida Lima Borba Lopes, Amanda; Cunha, Karin Soares; Milagres, Adrianna; Rozza-de-Menezes, Rafaela Elvira; Junior, Arley Silva; Conde, Danielle Castex
- Abstract
Background: The diagnosis of oral lichenoid lesions (OLL) remains a challenge for clinicians and pathologists. Although, in many cases, OLL cannot be clinically and histopathologically distinguishable from oral lichen planus (OLP), one important difference between these lesions is that OLL has an identifiable etiological factor, e.g. medication, restorative material, and food allergy. The list of drugs that can cause OLL is extensive and includes anti-inflammatory drugs, anticonvulsants, antihypertensives, antivirals, antibiotics, chemotherapeutics, among others. This work aimed to perform a literature review of OLL related to chemotherapy drugs and to report two cases of possible OLL in patients with B-cell and T-cell non-Hodgkin lymphomas in use of chemotherapy and adjuvant medications. We also discuss the challenge to clinically and histopathologically differentiate OLL and OLP. Case presentation: In both cases, oral lesions presented reticular, atrophic, erosive/ulcerated, and plaque patterns. The diagnosis of OLL was initially established in both cases by the association of histopathology and history of onset of lesions after the use of medications. Although the patients have presented a significant improvement in the oral clinical picture for more than 2 years of follow-up, they still have some lesions. Conclusion: A well-detailed anamnesis associated with the drug history, temporal relationship of the appearance of the lesions, and follow-up of patients are fundamental for the diagnosis of OLL related to drugs. Nevertheless, its differentiation from OLP is still a challenge.
- Subjects
LICHEN planus; NON-Hodgkin's lymphoma; CANCER treatment; ADJUVANT chemotherapy; ORAL lichen planus; LITERATURE reviews; MUCOSITIS
- Publication
Head & Face Medicine, 2022, Vol 18, Issue 1, p1
- ISSN
1746-160X
- Publication type
Article
- DOI
10.1186/s13005-022-00333-2