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- Title
Effects of N-acetyl cysteine on renal functions evaluated by blood neutrophil gelatinase-associated lipocalin levels in geriatric patients undergoing coronary artery bypass grafting.
- Authors
Aldemir, Mustafa; Koca, Halit Buğra; Bakı, Elif Doğan; Çarşanba, Görkem; Kavrut, Nilgün Öztürk; Kavaklı, Ali Sait; Adalı, Fahri; Emmiler, Mustafa; Darçın, Osman Tansel
- Abstract
Objective: Recent conflicting studies on the renal effects of N-acetyl cysteine (NAC) after cardiac surgery have been published. The aim of this study was to evaluate the renal effects of NAC using neutrophil gelatinase-associated lipocalin (NGAL) blood levels in elderly patients undergoing coronary artery bypass grafting (CABG). Methods: This randomized, double-blinded, placebo-controlled study was conducted among geriatric patients (>65 years) scheduled to undergo CABG. A total of 60 consecutive patients were randomly assigned to 2 groups. The first group received I.V. NAC (n=30) and the second group received placebo (n=30) at induction of anesthesia and then for 20 h. NGAL values were determined and conventional renal function tests were performed. Statistical analysis was performed using SPSS 17.0 (IL, Chicago, USA). A p value of <0.05 was considered statistically significant Results: Plasma creatinine levels at 24 h postoperatively were significantly higher in the placebo group than in the NAC group (1.41±0.63 vs. 1.13±0.35; p<0.05). The mean serum NGAL levels at 3 h postoperatively were higher in the placebo group than in the NAC group (104.94±30.51 vs. 87.82±25.18; p<0.05). NGAL levels were similar between the groups at all other measurement time points. Plasma creatinine levels of ≥1.5 mg/dL or >25% of the baseline value at any time during the study period were observed in 27% of patients in the NAC group and 37% of patients in the placebo group; the difference was statistically significant (p<0.05). Conclusion: In the present study, we found that I.V. NAC infusion in elderly patients undergoing CABG reduced the incidence of acute kidney injury as determined by blood NGAL and creatinine levels.
- Subjects
ACETYLCYSTEINE; COMPLICATIONS of cardiac surgery; CARDIAC rehabilitation; MEDICAL care of cardiac patients; NEUTROPHILS; LIPOCALINS; THERAPEUTICS
- Publication
Anatolian Journal of Cardiology / Anadolu Kardiyoloji Dergisi, 2016, Vol 16, Issue 7, p504
- ISSN
2149-2263
- Publication type
Article
- DOI
10.5152/AnatolJCardiol.2015.6287