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- Title
Impact of time‐varying confounders on the association between early‐life allergy sensitization and the risk of current asthma: A post hoc analysis of a birth cohort.
- Authors
Owora, Arthur H.; Li, Rui; Tepper, Robert S.; Ramsey, Clare D.; Chan‐Yeung, Moira; Watson, Wade T. A.; Becker, Allan B.
- Abstract
3 c MSM-2 results are adjusted for all time-invariant factors (sex, birth mode, gestational age, and low birth weight), time-varying allergy sensitization, time-varying asthma-related treatment exposure, and missing data (# multiple imputations = 20). Our results suggest that early life is an etiologically critical window during which allergy sensitization may induce pathogenesis towards school-age asthma onset irrespective of whether the pattern of sensitization is transient or persistent. Keywords: allergy sensitization; childhood asthma; marginal structural models EN allergy sensitization childhood asthma marginal structural models 3141 3144 4 09/30/22 20221001 NES 221001 Abbreviations aOR adjusted Odds Ratio CAPPS Canadian Asthma Primary Prevention Study CI confidence intervals GEE Generalized Estimating Equations IPTW inverse-probability-of-treatment (or exposure) weighted approach MSM Marginal Structural Models OR Odds Ratio Existing literature on the relationship between early-life (first year of life) allergy sensitization and risk of childhood asthma is mixed.1,2 This is in part due to the use of statistical analytic methods that ignore changes in both allergy sensitization status and asthma-related treatment exposure that may influence future asthma risk as a child grows older.
- Subjects
WHEEZE; ASTHMA; ALLERGIES; GENERALIZED estimating equations; COHORT analysis
- Publication
Allergy, 2022, Vol 77, Issue 10, p3141
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.15403