We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Association of ABCB1 polymorphisms with the efficacy of ondansetron for postoperative nausea and vomiting.
- Authors
Choi, E. M.; Lee, M. G.; Lee, S. H.; Choi, K. W.; Choi, S. H.
- Abstract
We investigated whether the 2677G>T/A and 3435C>T polymorphisms of adenosine triphosphate-binding cassette subfamily B member 1 ( ABCB1) affect the efficacy of ondansetron to prevent postoperative nausea and vomiting. One hundred and ninety-eight patients undergoing general anaesthesia were enrolled. Thirty minutes before the end of surgery, 0.1 mg.kg−1 ondansetron was administered intravenously. The incidence of postoperative nausea and vomiting was compared between genotypes in the 2677G>T/A and 3435C>T polymorphisms of ABCB1. The incidence of postoperative nausea and vomiting was lower in patients with the 2677TT genotype (TT vs Non-TT = 25.9% vs 53.0%, p = 0.01) and 3435TT genotype (CC + CT vs TT = 52.6% vs 21.7%, p = 0.01) during the first 2 h after surgery. There were no significant differences in the incidence of postoperative nausea and vomiting between the different genotype groupings during period between 2 and 24 h after surgery. In conclusion, ABCB1 genotypes may be a clinical predictor of responsiveness for ondansetron.
- Subjects
GENETIC polymorphisms; ONDANSETRON; POSTOPERATIVE nausea &; vomiting; ADENINE nucleotides; ANESTHESIA; POSTOPERATIVE care; THERAPEUTICS
- Publication
Anaesthesia, 2010, Vol 65, Issue 10, p996
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1111/j.1365-2044.2010.06476.x