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- Title
The effect of dexamethasone upon patient-controlled analgesia-related nausea and vomiting.
- Authors
Lee, Y; Lin, Y. S; Chen, Y. H
- Abstract
Ninety female patients were enrolled in this randomised, double-blind, placebo-controlled study to compare the anti-emetic effect of intravenous dexamethasone 8 mg with saline control in preventing patient-controlled analgesia-related nausea and vomiting following major orthopaedic surgery. The prophylactic administration of dexamethasone 8 mg significantly reduced the overall incidence of patient-controlled analgesia-related nausea and vomiting (p < 0.001) and the need for rescue anti-emetics (p < 0.01). Furthermore, patients who received dexamethasone showed a higher incidence of complete responses (no vomiting or need for rescue anti-emetic for a 24-h postoperative period) than those who received saline (p < 0.05). We conclude that dexamethasone 8 mg may be valuable for preventing patient-controlled analgesia-related nausea and vomiting in women undergoing major orthopaedic surgery.
- Subjects
ANTIEMETICS; POSTOPERATIVE nausea &; vomiting; THERAPEUTICS
- Publication
Anaesthesia, 2002, Vol 57, Issue 7, p690
- ISSN
0003-2409
- Publication type
Article
- DOI
10.1046/j.1365-2044.2002.02572_5.x