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- Title
Sustained Delivery of Olopatadine from Vitamin-E Loaded Contact Lenses.
- Authors
Reis, Inês M.; Dixon, Philip J.; Sekar, Poorvajan; Chauhan, Anuj
- Abstract
Purpose: Topical antihistamines, such as olopatadine hydrochloride, an H1 receptor antagonist, are commonly prescribed for treating allergic conjunctivitis. Drug delivery via eye drops has many deficiencies including a short residence time due to tear drainage via the nasolacrimal duct, which results in a low bioavailability and potential for side effects. These deficiencies could be mitigated by a drug-eluting contact lens such as the recently approved ACUVUE® THERAVISION™ WITH KETOTIFEN which is a daily disposable etafilcon, a drug-eluting contact lens with ketotifen (19 μg per lens). Here, we investigate the feasibility of designing a drug-eluting lens with sustained release of olopatadine for treating allergies using an extended wear lens. Methods: Nanobarrier depots composed of vitamin-E (VE) are formed through direct entrapment by ethanol-driven swelling. The drug-loaded lenses are characterized for transparency and water content. In vitro release is measured under sink conditions and fitted to a diffusion control release model to determine diffusivity and partition coefficient. Results:In vitro studies indicate that ACUVUE OASYS® and ACUVUE TruEye™ lenses loaded with ∼0.3 g of VE/g of hydrogel effectively prolong olopatadine dynamics by 7-fold and 375-fold, respectively. Incorporation of VE into the lenses retains visible light transmission and other properties. Conclusion: The VE incorporation in commercial lenses significantly increases the release duration offering the possibility of antiallergy extended wear lenses.
- Subjects
CONTACT lenses; OPHTHALMIC drugs; ALLERGIC conjunctivitis; LACRIMAL apparatus; EYE drops; ANTIALLERGIC agents; DIFFUSION control; VITAMIN E
- Publication
Journal of Ocular Pharmacology & Therapeutics, 2024, Vol 40, Issue 2, p126
- ISSN
1080-7683
- Publication type
Article
- DOI
10.1089/jop.2023.0111