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- Title
Chronic exposure to high glucose and impairment of K(+)-channel function in perifused rat pancreatic islets.
- Authors
Purrello, Francesco; Vetri, Mario; Vinci, Carmela; Gatta, Concetta; Buscema, Massimo; Vigneri, Riccardo; Purrello, F; Vetri, M; Vinci, C; Gatta, C; Buscema, M; Vigneri, R
- Abstract
Prolonged exposure to high glucose levels impairs the ability of pancreatic islets to secrete insulin as a response to that stimulus. Because glucose, like other insulin secretagogues, elicits insulin secretion by inhibiting the ATP-sensitive K+ channels, in this study, we investigated the effect of prolonged (24-h) exposure of rat pancreatic islets to high (16.7 mM) glucose concentration on 86Rb efflux (used as a tracer for K+). The data obtained indicate that islets exposed to high glucose concentration have impaired function of the glucose-sensitive K+ channel, this phenomenon is temporarily related to a defective response of glucose-induced insulin release, and these alterations are reversible.
- Publication
Diabetes, 1990, Vol 39, Issue 3, p397
- ISSN
0012-1797
- Publication type
journal article
- DOI
10.2337/diabetes.39.3.397