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- Title
Microbiota Contribute to Obesity-related Increases in the Pulmonary Response to Ozone.
- Authors
Hiroki Tashiro; Youngji Cho; Kasahara, David I.; Brand, Jeffrey D.; Bry, Lynn; Yeliseyev, Vladimir; Abu-Ali, Galeb; Huttenhower, Curtis; Shore, Stephanie A.
- Abstract
Obesity is a risk factor for asthma, especially nonatopic asthma, and attenuates the efficacy of standard asthma therapeutics. Obesity also augments pulmonary responses to ozone, a nonatopic asthma trigger. The purpose of this study was to determine whether obesity-related alterations in gut microbiota contribute to these augmented responses to ozone. Ozone-induced increases in airway responsiveness, a canonical feature of asthma, were greater in obese db/db mice than in lean wild-type control mice. Depletion of gut microbiota with a cocktail of antibiotics attenuated obesity- related increases in the response to ozone, indicating a role for microbiota. Moreover, ozone-induced airway hyperresponsiveness was greater in germ-free mice that had been reconstituted with colonic contents of db/db than in wild-type mice. In addition, compared with dietary supplementation with the nonfermentable fiber cellulose, dietary supplementation with the fermentable fiber pectin attenuated obesity-related increases in the pulmonary response to ozone, likely by reducing ozone-induced release of IL-17A. Our data indicate a role for microbiota in obesity-related increases in the response to an asthma trigger and suggest that microbiome-based therapies such as prebiotics may provide an alternative therapeutic strategy for obese patients with asthma.
- Subjects
LUNG diseases; LUNG disease treatment; EPITHELIAL cells; OBESITY treatment; DIETARY supplements
- Publication
American Journal of Respiratory Cell & Molecular Biology, 2019, Vol 61, Issue 6, p702
- ISSN
1044-1549
- Publication type
Article
- DOI
10.1165/rcmb.2019-0144OC