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- Title
Hyperuricemia and tumor lysis syndrome in children with non-Hodgkin's lymphoma and acute lymphoblastic leukemia.
- Authors
Sevinir, Betül; Demirkaya, Metin; Baytan, Birol; Güneş, Adalet Meral
- Abstract
Objective: This study aimed to examine the incidence, clinical characteristics, and outcome of hyperuricemia and tumor lysis syndrome (TLS) in children with non-Hodgkin's lymphoma (NHL) and acute lymphoblastic leukemia (ALL). Materials and Methods: This retrospective study included data from 327 patients (113 NHL and 214 ALL). Results: Hyperuricemia occurred in 26.5% and 12.6% of the patients with NHL and ALL, respectively. The corresponding figures for TLS were 15.9% and 0.47% (p=0.001). All hyperuricemic NHL patients had advanced disease and renal involvement was present in 53%. All hyperuricemic ALL patients had a leukocyte count >50,000 mm³ at the time of diagnosis. Among the hyperuricemic NHL and ALL patients, 96.6% and 66.6% had LDH ≥500 UI/L, respectively. Treatment consisted of hydration and allopurinol;none of the patients received urate oxidase. Among the patients that developed TLS, 26.3% had laboratory TLS, 42.1% had grade I or II TLS, and 31.6% had grade III or IV TLS. Uric acid levels returned to normal after a mean period of 3.5±2.5 and 3.05±0.8 d in NHL and ALL groups, respectively. In all, 7% of the patients with hyperuricemia required hemodialysis. None of the patients died. Conclusion: In this series the factors associated with a high-risk for TLS were renal involvement in NHL and high leucocyte count in ALL. Management with allopurinol and hydration was effective in this group of patients with high tumor burden.
- Subjects
TURKEY; ANALYSIS of variance; CANCER chemotherapy; CHI-squared test; COMPUTER software; ENZYME inhibitors; LYMPHOBLASTIC leukemia; LYMPHOMAS; LYMPHOPROLIFERATIVE disorders; MEDICAL protocols; METABOLIC disorders; HEALTH outcome assessment; T-test (Statistics); URIC acid; DATA analysis; TREATMENT effectiveness; DISEASE incidence; RETROSPECTIVE studies; DRUG dosage
- Publication
Turkish Journal of Hematology, 2011, Vol 28, Issue 1, p52
- ISSN
1300-7777
- Publication type
Article
- DOI
10.5152/tjh.2011.06