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- Title
Amaranthus mangostanus Inhibits the Differentiation of Osteoclasts and Prevents Ovariectomy-Induced Bone Loss.
- Authors
Jeong, Yeon-Hui; Hur, Haeng Jeon; Lee, Ae Sin; Lee, Sang Hee; Sung, Mi Jeong
- Abstract
Bone homeostasis is dynamically balanced between bone forming osteoblasts and bone resorbing osteoclasts. Osteoclasts play an important role in bone destruction and osteoporosis, and they are derived from monocyte/macrophages in response to macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor κB (NF-κB) ligand (RANKL). Amaranthus mangostanus L. (AM) is a plant with powerful antioxidant and other biological activities including anti-inflammatory, antidiabetic, and antihyperlipidemic effects. However, its effects on bone health are unknown. In this study, we explored whether AM could affect RANK-mediated osteoclastogenesis. AM significantly suppressed RANKL-induced osteoclast differentiation and expression of osteoclast-specific genes, TRAP, cathepsin K, NF-activated T-cells (NFATc1), and Dc-stamp in RAW 264.7 cells. Moreover, AM significantly inhibited extracellular signal-regulated kinase (ERK), Akt, and NF-κB signaling pathways in RAW 264.7 cells. In addition, AM preserved ovariectomy-induced bone loss in mice. Taken together, our results suggest that AM might be a potential candidate for the treatment of postmenopausal osteoporosis.
- Subjects
OSTEOPOROSIS prevention; ACID phosphatase; ANIMAL experimentation; CARBOHYDRATES; CELL differentiation; CELLULAR signal transduction; EXTRACELLULAR space; GENE expression; MICE; MOLECULAR structure; OSTEOPOROSIS; OVARIECTOMY; PROTEIN kinases; PROTEOLYTIC enzymes; HYDROXY acids; DNA-binding proteins; PLANT extracts; ACYCLIC acids
- Publication
Evidence-based Complementary & Alternative Medicine (eCAM), 2020, p1
- ISSN
1741-427X
- Publication type
Article
- DOI
10.1155/2020/1927017