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- Title
Aneuploidy: a common and early evidencebased biomarker for carcinogens and reproductive toxicants.
- Authors
Mandrioli, Daniele; Belpoggi, Fiorella; Silbergeld, Ellen K.; Perry, Melissa J.
- Abstract
Aneuploidy, defined as structural and numerical aberrations of chromosomes, continues to draw attention as an informative effect biomarker for carcinogens and male reproductive toxicants. It has been well documented that aneuploidy is a hallmark of cancer. Aneuploidies in oocytes and spermatozoa contribute to infertility, pregnancy loss and a number of congenital abnormalities, and sperm aneuploidy is associated with testicular cancer. It is striking that several carcinogens induce aneuploidy in somatic cells, and also adversely affect the chromosome compliment of germ cells. In this paper we review 1) the contributions of aneuploidy to cancer, infertility, and developmental abnormalities; 2) techniques for assessing aneuploidy in precancerous and malignant lesions and in sperm; and 3) the utility of aneuploidy as a biomarker for integrated chemical assessments of carcinogenicity, and reproductive and developmental toxicity.
- Subjects
ANEUPLOIDY; PLOIDY; CARCINOGENICITY; ENVIRONMENTALLY induced cancer; HAZARDOUS substances
- Publication
Environmental Health: A Global Access Science Source, 2016, Vol 15, p1
- ISSN
1476-069X
- Publication type
Article
- DOI
10.1186/s12940-016-0180-6