We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Personality traits and polymorphisms of genes coding neurotransmitter receptors or transporters: review of single gene and genome-wide association studies.
- Authors
Zmorzyński, Szymon; Styk, Wojciech; Klinkosz, Waldemar; Iskra, Justyna; Filip, Agata Anna
- Abstract
Background: The most popular tool used for measuring personality traits is the Five-Factor Model (FFM). It includes neuroticism, extraversion, openness, agreeableness and conscientiousness. Many studies indicated the association of genes encoding neurotransmitter receptors/transporters with personality traits. The relationship connecting polymorphic DNA sequences and FFM features has been described in the case of genes encoding receptors of cannabinoid and dopaminergic systems. Moreover, dopaminergic system receives inputs from other neurotransmitters, like GABAergic or serotoninergic systems. Methods: We searched PubMed Central (PMC), Science Direct, Scopus, Cochrane Library, Web of Science and EBSCO databases from their inception to November 19, 2020, to identify original studies, as well as peer-reviewed studies examining the FFM and its association with gene polymorphisms affecting the neurotransmitter functions in central nervous system. Results: Serotonin neurons modulate dopamine function. In gene encoding serotonin transporter protein, SLC6A4, was found polymorphism, which was correlated with openness to experience (in Sweden population), and high scores of neuroticism and low levels of agreeableness (in Caucasian population). The genome-wide association studies (GWASs) found an association of 5q34-q35, 3p24, 3q13 regions with higher scores of neuroticism, extraversion and agreeableness. However, the results for chromosome 3 regions are inconsistent, which was shown in our review paper. Conclusions: GWASs on polymorphisms are being continued in order to determine and further understand the relationship between the changes in DNA and personality traits.
- Subjects
CARRIER proteins; CENTRAL nervous system; CHROMOSOMES; COMPARATIVE studies; DNA; DOPAMINE; GENES; GENETIC polymorphisms; GENOMES; INFORMATION storage &; retrieval systems; MEDICAL databases; MATHEMATICAL models; MEDLINE; MEMBRANE proteins; NEURONS; NEUROSES; NEUROTRANSMITTER receptors; ONLINE information services; PERSONALITY; PSYCHOLOGY; SEROTONIN; SYSTEMATIC reviews
- Publication
Annals of General Psychiatry, 2021, Vol 20, Issue 1, p1
- ISSN
1744-859X
- Publication type
Article
- DOI
10.1186/s12991-021-00328-4