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- Title
Spinal ependymomas: Prognostic factors and treatment results.
- Authors
Voulgaris, Spyridon; Alexiou, George A.; Zigouris, Andreas; Fotakopoulos, George; Michos, Evaggelos; Katsiafas, Ioannis; Savvanis, George; Pachatouridis, Dimitrios
- Abstract
Objective: We retrospectively analyzed patients with spinal ependymomas who were treated in our institute. We correlated outcome and recurrence with clinical and pathological features. Materials and Methods: Between January 2000 and January 2010, we treated 14 patients with spinal ependymoma (10 males, 4 females; mean age: 48.3±18 years, range: 18-79 years). All patients were operated and received standard postoperative care. The outcome was estimated based on Frankel scale. Results: The most common presenting symptom was pain. All tumors were operated through a posterior approach and gross total resection was performed in 13/14 cases. Histopathological examination revealed the presence of one anaplastic ependymoma, nine grade II ependymomas, and four myxopapillary ependymomas. The mean Ki-67 index was 1.5%. All the patients were followed up postoperatively for an average of 5.1 years. One patient was reoperated because of recurrent disease and another received radiotherapy due to dissemination of disease. No association was found between extent of resection, tumor location, Ki-67 index, and recurrence of disease. There was a trend toward a higher risk of recurrence in myxopapillary ependymomas. Eight patients improved postoperatively. Interestingly, during the follow-up period, four patients developed a secondary neoplasia. Conclusion: Early intervention and gross total resection of spinal ependymomas are associated with a favorable outcome. Further studies are needed to clarify the incidence of the development of a second cancer in these patients.
- Subjects
SPINAL cord tumors; CANCER relapse; POSTOPERATIVE care; CANCER histopathology; CANCER radiotherapy; CANCER invasiveness; HEALTH outcome assessment; RETROSPECTIVE studies; TUMOR treatment
- Publication
Journal of Cancer Research & Therapeutics, 2013, Vol 9, Issue 1, p60
- ISSN
0973-1482
- Publication type
Article
- DOI
10.4103/0973-1482.110371