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- Title
Clinical and serological features of systemic sclerosis in a Chinese cohort.
- Authors
Wang, Jiucun; Assassi, Shervin; Guo, Gang; Tu, Wenzhen; Wu, Wenyu; Yang, Li; Xiao, Rong; Zhao, Yongqiang; Chu, Haiyan; Liu, Jie; Ma, Yanyun; Kim, Sarah; Jin, Li; Mayes, Maureen; Zou, Hejian; Zhou, Xiaodong
- Abstract
Our goal was to study the prevalence of systemic sclerosis (SSc) subtypes, autoantibody profile, and pulmonary fibrosis in a large group of Han Chinese. Chinese SSc patients ( n = 419) were recruited from a multicenter study including hospitals and outpatient clinics in China. All patients met the American College of Rheumatology classification criteria for SSc. Anti-topoisomerase (ATA), anti-centromere (ACA), anti-RNA polymerase III (anti-RNAP3), and anti-U1-ribonucleoprotein (anti-U1RNP) were detected utilizing commercially available kits. The clinical and autoantibody information in Chinese patients was compared to that in the US Caucasian patients ( n = 834), recruited from the Genetics versus Environment in Scleroderma Outcome Study and Scleroderma Family Registry. Chi-square test was utilized for the abovementioned comparisons. Chinese patients showed 40.3 % limited (lcSSc) and 59.7 % diffuse (dcSSc) forms of SSc. ATA was found in 59.9 %, ACA in 13.4 %, anti-RNAP3 in 1.3 %, and anti-U1RNP in 18 % of Chinese SSc patients. Compared to US patients (65.1 % lcSSc, 34.9 % dcSSc, ATA in 18.7 %, ACA in 32.4 %, anti-RNAP3 in 17.4 %, and anti-U1RNP in 2.8 %), Chinese SSc patients are significantly higher in dcSSc and the frequencies of ATA and anti-U1RNP, but lower in ACA and anti-RNAP3. In addition, pulmonary fibrosis was observed in 78 % Chinese SSc patients and was strongly associated with the presence of ATA. The present study represents the first report of SSc features in a large group of Chinese patients. Clinical subtypes and the frequencies of SSc-related autoantibodies in Chinese SSc patients are significantly different from those in SSc patients of the US Caucasian descent.
- Subjects
SYSTEMIC scleroderma; DISEASE prevalence; AUTOANTIBODIES; PULMONARY fibrosis; OUTPATIENT medical care; RHEUMATOLOGY; CHINESE people; DISEASES
- Publication
Clinical Rheumatology, 2013, Vol 32, Issue 5, p617
- ISSN
0770-3198
- Publication type
Article
- DOI
10.1007/s10067-012-2145-7