We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Feasibility and Outcome of Reduced-Intensity Conditioning in Haploidentical Transplantation.
- Authors
HANDGRETINGER, RUPERT; CHEN, XIAOHUA; PFEIFFER, MATTHIAS; MUELLER, INGO; FEUCHTINGER, TOBIAS; HALE, GREGORY A.; LANG, PETER
- Abstract
Allogeneic stem cell transplantation is for a number of patients with malignant and nonmalignant diseases the only curative approach. For those patients who do not have an HLA-identical–related or –unrelated stem cell donor, a related three-loci mismatch haploidentical stem cell transplantation with T cell-depleted stem cells is a viable option. T cell depletion either by CD34+ positive selection or by CD3-negative depletion strategies is available and has been investigated. We have shown that reduced-intensity conditioning haploidentical transplantation using mobilized peripheral stem cells negatively depleted from T and B lymphocytes is associated with a rapid immune reconstitution, a low transplant-related mortality rate, and a favorable outcome in patients in remission at the time of transplant. For chemorefractory patients, additional posttransplant cellular and humoral immunotherapeutic strategies are needed for prevention of relapse after transplantation.
- Subjects
STEM cells; CELL transplantation; T cells; LEUCOCYTES; GRAFT versus host disease; CELLULAR therapy; LYMPHOCYTES
- Publication
Annals of the New York Academy of Sciences, 2007, Vol 1106, p279
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1196/annals.1392.022