We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Myocardial Na,K-ATPase and Digoxin Therapy in Human Heart Failure.
- Authors
KJELDSEN, KELD; BUNDGAARD, HENNING
- Abstract
A bstract: The specific binding of digitalis glycosides to the Na,K-ATPase is used as a tool for Na,K-ATPase quantification with high accuracy and precision. In myocardial biopsies from patients with heart failure, total Na,K-ATPase concentration is decreased, and the decrease in Na,K-ATPase concentration correlates with a decrease in heart function. During digitalization, a fraction of remaining pumps are occupied by digoxin. No evidence for an endogenous digitalis-like factor of any clinical importance was obtained. It is recommended that digoxin be administered to heart failure patients who still have dyspnea after institution of mortality-reducing therapy.
- Publication
Annals of the New York Academy of Sciences, 2003, Vol 986, Issue 1, p702
- ISSN
0077-8923
- Publication type
Article
- DOI
10.1111/j.1749-6632.2003.tb07285.x