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- Title
Pseudocholinesterase Deficiency Considerations: A Case Study.
- Authors
Cornelius, Bryant W.; Jacobs, Todd M.
- Abstract
Pseudocholinesterase deficiency, sometimes called butyrylcholinesterase deficiency, is a rare disorder in which the neuromuscular blocking drugs succinylcholine and mivacurium cannot be metabolized properly in the blood plasma. This disorder can either be acquired as a result of certain comorbidities or it can be inherited genetically. Anesthesia providers must understand the pathophysiology of pseudocholinesterase deficiency and be prepared to safely and effectively manage patients who show signs and symptoms consistent with the disorder after the use of the indicated neuromuscular blocking drugs. This article summarizes the pharmacologic and physiologic data relevant to understanding the basic pathophysiology associated with pseudocholinesterase deficiency and illustrates a case study of a young woman suspected of having the disorder after a prolonged delay in emergence from general anesthesia.
- Subjects
SUCCINYLCHOLINE; APNEA; CHOLINESTERASES; QUESTIONNAIRES; INBORN errors of metabolism
- Publication
Anesthesia Progress, 2020, Vol 67, Issue 3, p177
- ISSN
0003-3006
- Publication type
journal article
- DOI
10.2344/anpr-67-03-16