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- Title
Hepatoprotective Effect of Arctium lappa Root Extract on Cadmium Toxicity in Adult Wistar Rats.
- Authors
Souza Predes, Fabricia; Silva Diamante, Maria; Foglio, Mary; Camargo, Camila; Aoyama, Hiroshi; Miranda, Silvio; Cruz, Bread; Gomes Marcondes, Maria; Dolder, Heidi
- Abstract
This study was performed to determine the effects of Arctium lappa ( Al) to protect against cadmium damage in the rat liver. Male rats received a single i.p. dose of CdCl (1.2 mg/kg body weight (BW)) with or without Al extract administered daily by gavage (300 mg/kg BW) for 7 or 56 days. After 7 days, Al caused plasma transaminase activity to diminish in groups Al (glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT)) and Cd Al (GPT). After 56 days, GOT and GPT plasma activities were reduced in the Cd group. No alteration in plasma levels of creatinine, total bilirubin, and total protein were observed. GOT liver activity increased in the Cd group. No alteration was observed in superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), and malondialdehyde (MDA) dosage. In the Cd group, hepatocyte proportion decreased and sinusoid capillary proportion increased. In the Al and Cd Al groups, the nuclear proportion increased and the cytoplasmic proportion decreased. The hepatocyte nucleus density reduced in Cd and increased in the Al group. After 56 days, there was no alteration in the Cd group. In Al and Cd Al groups, the nuclear proportion increased without cytoplasmic proportion variation, but the sinusoid capillary proportion was reduced. The hepatocyte nucleus density decreased in the Cd group and increased in the Al and Cd Al groups. In conclusion, the liver function indicators showed that A. lappa protected the liver against cadmium toxicity damage.
- Subjects
RATS; OXYGEN; CADMIUM; LIVER displacement; HEPATOPULMONARY syndrome
- Publication
Biological Trace Element Research, 2014, Vol 160, Issue 2, p250
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-014-0040-6