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- Title
Selenium Deficiency Is Associated with Endoplasmic Reticulum Stress in a Rat Model of Cardiac Malfunction.
- Authors
Wang, Su-Qin; Niu, Xiao-Lin; Liu, Zhong-Wei; Zhu, Yan-He; Gao, Deng-Feng
- Abstract
The relationship between selenium (Se) deficiency-induced cardiac malfunction and endoplasmic reticulum (ER) stress is poorly understood. In the present study, 18 weaning Sprague Dawley rats were randomly fed with three different Se diets, and myocardial glutathione peroxidase (GPx) activity was measured by an enzyme activity assay. Cardiac function was evaluated by hemodynamic parameters. ER stress markers immunoglobulin-binding protein (BiP)/glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) were detected by western blotting. Our data showed that myocardial GPx activity and cardiac function were conspicuously impaired in Se-deficient rats. Expression of GRP78 and CHOP was significantly upregulated by treatment of Se deficiency. Improvements in myocardial GPx activity and cardiac function, as well as decreases in expression of GRP78 and CHOP, were observed after Se supplementation. Consequently, our data show that ER stress was involved in Se deficiency-induced cardiac dysfunction.
- Subjects
SELENIUM deficiency diseases in animals; ENDOPLASMIC reticulum; HEART disease risk factors; SPRAGUE Dawley rats; GLUTATHIONE peroxidase; MAMMAL physiology; OXIDATIVE stress; PHYSIOLOGY
- Publication
Biological Trace Element Research, 2013, Vol 155, Issue 3, p196
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-013-9834-1