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- Title
Cover Picture: Direct Catalytic Addition of Alkylnitriles to Aldehydes by Transition-Metal/NHC Complexes (Chem. Eur. J. 48/2014).
- Authors
Sureshkumar, Devarajulu; Ganesh, Venkataraman; Kumagai, Naoya; Shibasaki, Masakatsu
- Abstract
Direct catalytic addition of alkylnitriles to aldehydes allows for an atom ‐ economical access to β ‐ hydroxynitriles under proton ‐ transfer conditions. A transition metal/N ‐ heterocyclic carbene (NHC) complex prepared from [Rh(OMe)(cod)]2 and an imidazolium ‐ based carbene was identified as an effective catalyst to promote the reaction with as little as 1.25 mol % of catalyst loading. The corresponding Rh complex derived from chiral triazolium salt rendered the reaction enantioselective, albeit with moderate enantioselectivity. For full details, see the Communication by N. Kumagai, M. Shibasaki et al. on page 15723 ff.
- Subjects
ALDEHYDES; CATALYSIS
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 48, p15637
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201490198