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- Title
Domino-Hydroformylation/Aldol Condensation Catalysis: Highly Selective Synthesis of α,β-Unsaturated Aldehydes from Olefins.
- Authors
Fang, Xianjie; Jackstell, Ralf; Franke, Robert; Beller, Matthias
- Abstract
A general and highly chemo-, regio-, and stereoselective synthesis of α,β-unsaturated aldehydes by a domino hydroformylation/aldol condensation reaction has been developed. A variety of olefins and aromatic aldehydes were efficiently converted into various substituted α,β-unsaturated aldehydes in good to excellent yields in the presence of a rhodium phosphine/acid-base catalyst system. In view of the easy availability of the substrates, the high atom-efficiency, the excellent selectivity, and the mild conditions, this method is expected to complement current methodologies for the preparation of α,β-unsaturated aldehydes.
- Subjects
HYDROFORMYLATION; ALDOLS; RHODIUM; ALDEHYDES; CARBONYLATION
- Publication
Chemistry - A European Journal, 2014, Vol 20, Issue 41, p13210
- ISSN
0947-6539
- Publication type
Article
- DOI
10.1002/chem.201403302