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- Title
Silver Clusters of Five Atoms as Highly Selective Antitumoral Agents Through Irreversible Oxidation of Thiols (Adv. Funct. Mater. 29/2022).
- Authors
Porto, Vanesa; Buceta, David; Domínguez, Blanca; Carneiro, Carmen; Borrajo, Erea; Fraile, María; Davila‐Ferreira, Nerea; Arias, Iria R.; Blanco, José M.; Blanco, Maria C.; Devida, Juan M.; Giovanetti, Lisandro J.; Requejo, Félix G.; Hernández‐Garrido, Juan C.; Calvino, José J.; López‐Haro, Miguel; Barone, Giampaolo; James, Andrew M.; García‐Caballero, Tomás; González‐Castaño, Diego M.
- Abstract
Cancer therapy, catalysis, low atomicity clusters, silver clusters, sulfur oxidation Keywords: cancer therapy; catalysis; low atomicity clusters; silver clusters; sulfur oxidation EN cancer therapy catalysis low atomicity clusters silver clusters sulfur oxidation 1 1 1 07/20/22 20220718 NES 220718 B Antitumoral Agents b In article number 2113028, M. Arturo López-Quintela, Fernando Domínguez, and co-workers report that Ag SB 5 sb clusters show unique catalytic activities to oxidize thiols. This oxidation is tunable by relevant biological oxidants species (hydrogen peroxide and hydroxyl radical), allowing Ag SB 5 sb to inhibit the thiol-based antioxidants leading to the selective death of tumor proliferating cells.
- Subjects
SILVER clusters; ATOMIC clusters; THIOLS; OXIDATION; HYDROXYL group
- Publication
Advanced Functional Materials, 2022, Vol 32, Issue 29, p1
- ISSN
1616-301X
- Publication type
Article
- DOI
10.1002/adfm.202270166