We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Making smart drugs smarter: The importance of linker chemistry in targeted drug delivery.
- Authors
Yang, Xiaoxiao; Pan, Zhixiang; Choudhury, Manjusha R.; Yuan, Zhengnan; Anifowose, Abiodun; Yu, Bingchen; Wang, Wenyi; Wang, Binghe
- Abstract
Smart drugs, such as antibody‐drug conjugates, for targeted therapy rely on the ability to deliver a warhead to the desired location and to achieve activation at the same site. Thus, designing a smart drug often requires proper linker chemistry for tethering the warhead with a vehicle in such a way that either allows the active drug to retain its potency while being tethered or ensures release and thus activation at the desired location. Recent years have seen much progress in the design of new linker activation strategies. Herein, we review the recent development of chemical strategies used to link the warhead with a delivery vehicle for preferential cleavage at the desired sites.
- Subjects
TARGETED drug delivery; PHARMACEUTICAL chemistry; ANTIBODY-drug conjugates
- Publication
Medicinal Research Reviews, 2020, Vol 40, Issue 6, p2682
- ISSN
0198-6325
- Publication type
Article
- DOI
10.1002/med.21720