We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
4D magnetic resonance flow imaging for estimating pulmonary vascular resistance in pulmonary hypertension.
- Authors
Kheyfets, Vitaly O.; Schafer, Michal; Podgorski, Chris A.; Schroeder, Joyce D.; Browning, James; Hertzberg, Jean; Buckner, J. Kern; Hunter, Kendal S.; Shandas, Robin; Fenster, Brett E.
- Abstract
<bold>Purpose: </bold>To develop an estimate of pulmonary vascular resistance (PVR) using blood flow measurements from 3D velocity-encoded phase contract magnetic resonance imaging (here termed 4D MRI).<bold>Materials and Methods: </bold>In all, 17 patients with pulmonary hypertension (PH) and five controls underwent right heart catheterization (RHC), 4D and 2D Cine MRI (1.5T) within 24 hours. MRI was used to compute maximum spatial peak systolic vorticity in the main pulmonary artery (MPA) and right pulmonary artery (RPA), cardiac output, and relative area change in the MPA. These parameters were combined in a four-parameter multivariate linear regression model to arrive at an estimate of PVR. Agreement between model predicted and measured PVR was also evaluated using Bland-Altman plots. Finally, model accuracy was tested by randomly withholding a patient from regression analysis and using them to validate the multivariate equation.<bold>Results: </bold>A decrease in vorticity in the MPA and RPA were correlated with an increase in PVR (MPA: R(2) = 0.54, P < 0.05; RPA: R(2) = 0.75, P < 0.05). Expanding on this finding, we identified a multivariate regression equation that accurately estimates PVR (R(2) = 0.94, P < 0.05) across severe PH and normotensive populations. Bland-Altman plots showed 95% of the differences between predicted and measured PVR to lie within 1.49 Wood units. Model accuracy testing revealed a prediction error of ∼20%.<bold>Conclusion: </bold>A multivariate model that includes MPA relative area change and flow characteristics, measured using 4D and 2D Cine MRI, offers a promising technique for noninvasively estimating PVR in PH patients. J. MAGN. RESON. IMAGING 2016;44:914-922.
- Subjects
BLOOD flow measurement; DIAGNOSTIC imaging; HEMODYNAMICS; MAGNETIC resonance imaging; VASCULAR resistance; COMPUTERS in medicine; PULMONARY artery; PULMONARY circulation; PULMONARY hypertension; RESEARCH evaluation; RESEARCH funding; MAGNETIC resonance angiography
- Publication
Journal of Magnetic Resonance Imaging, 2016, Vol 44, Issue 4, p914
- ISSN
1053-1807
- Publication type
journal article
- DOI
10.1002/jmri.25251