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- Title
Cardiac adaptation to exercise training in health and disease.
- Authors
Seo, Dae Yun; Kwak, Hyo-Bum; Kim, Amy Hyein; Park, Se Hwan; Heo, Jun Won; Kim, Hyoung Kyu; Ko, Jeong Rim; Lee, Sam Jun; Bang, Hyun Seok; Sim, Jun Woo; Kim, Min; Han, Jin
- Abstract
The heart is the primary pump that circulates blood through the entire cardiovascular system, serving many important functions in the body. Exercise training provides favorable anatomical and physiological changes that reduce the risk of heart disease and failure. Compared with pathological cardiac hypertrophy, exercise-induced physiological cardiac hypertrophy leads to an improvement in heart function. Exercise-induced cardiac remodeling is associated with gene regulatory mechanisms and cellular signaling pathways underlying cellular, molecular, and metabolic adaptations. Exercise training also promotes mitochondrial biogenesis and oxidative capacity leading to a decrease in cardiovascular disease. In this review, we summarized the exercise-induced adaptation in cardiac structure and function to understand cellular and molecular signaling pathways and mechanisms in preclinical and clinical trials.
- Subjects
CARDIOVASCULAR system; CARDIAC hypertrophy; REGULATOR genes; HEART diseases; PHYSIOLOGICAL adaptation
- Publication
Pflügers Archiv: European Journal of Physiology, 2020, Vol 472, Issue 2, p155
- ISSN
0031-6768
- Publication type
Article
- DOI
10.1007/s00424-019-02266-3