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- Title
Electrically Polarized Withaferin A and Alginate-Incorporated Biphasic Calcium Phosphate Microspheres Exhibit Osteogenicity and Antibacterial Activity In Vitro.
- Authors
Priyadarshini, Itishree; Swain, Subhasmita; Koduru, Janardhan Reddy; Rautray, Tapash Ranjan
- Abstract
Biphasic calcium phosphate microspheres were synthesized by the water on oil emulsion method and, subsequently, withaferin A was incorporated in the microspheres to evaluate their efficacy in biomedical applications. These withaferin A and alginate-incorporated biphasic calcium phosphate (BCP-WFA-ALG) microspheres were then negatively polarized, and the formation of biphasic calcium phosphates was validated by X-ray diffraction study. Although the TSDC measurement of the BCP-WFA-ALG microspheres showed the highest current density of 5.37 nA/cm2, the contact angle of the specimen was found to be lower than the control BCP microspheres in all the media. The water uptake into BCP-WFA-ALG microspheres was significantly higher than in the pure BCP microspheres. MTT assay results showed that there was a significant enhancement in cell proliferation rate with the BCP-WFA-ALG composite microspheres. The osteogenic differentiation of MG 63 cells on BCP-WFA-ALG microspheres exhibited an increased expression of osteogenic marker genes in the case of the BCP-WFA-ALG composite microspheres.
- Subjects
CALCIUM phosphate; MICROSPHERES; ANTIBACTERIAL agents; INSULIN aspart; CONTACT angle; X-ray diffraction
- Publication
Molecules, 2023, Vol 28, Issue 1, p86
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28010086