We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Fe(III) Complexes Based on Mono - and Bis-pyrazolyl- s -triazine Ligands: Synthesis, Molecular Structure, Hirshfeld, and Antimicrobial Evaluations.
- Authors
Soliman, Saied M.; Al-Rasheed, Hessa H.; Albering, Jörg H.; El-Faham, Ayman; Silva, Vera L. M.; Silva, Artur M. S.
- Abstract
The self-assembly of iron(III) chloride with three pyrazolyl-s-triazine ligands, namely 2,4-bis(3,5-dimethyl-1H-pyrazol-1-yl)-6-(piperidin-1-yl)-1,3,5-triazine (PipBPT), 4-(4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazin-2-yl)morpholine (MorphBPT), and 4,4'-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine-2,4-diyl)dimorpholine (bisMorphPT) afforded [Fe(PipBPT)Cl2][FeCl4] (1), [Fe(MorphBPT)Cl2][FeCl4] (2), and [H(bisMorphPT)][FeCl4]. bisMorphPT.2H2O (3), respectively, in good yield. In complexes 1 and 2, the Fe(III) is pentacoordinated with three Fe-N interactions from the pincer ligand and two coordinated chloride anions in the inner sphere, and FeCl4¯ in the outer sphere. Complex 3 is comprised of one protonated ligand as cationic part, one FeCl4¯ anion, and one neutral bisMorphPT molecule in addition to two crystallized water molecules. Analysis of molecular packing using Hirshfeld calculations indicated that H...H and Cl...H are the most important in the molecular packing. They comprised 40.1% and 37.4%, respectively in 1 and 32.4% and 37.8%, respectively in 2. Complex 1 exhibited the most bioactivity against the tested microbes while 3 had the lowest bioactivity. The bisMorphPT and MorphBPT were inactive towards the tested microbes while PipBPT was active. As a whole, the Fe(III) complexes have enhanced antibacterial and antifungal activities as compared to the free ligands.
- Subjects
MOLECULAR structure; LIGANDS (Biochemistry); SCHIFF bases; TRIAZINE derivatives; TRIAZINES; MORPHOLINE; ANIONS; SPHERES
- Publication
Molecules, 2020, Vol 25, Issue 23, p5750
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules25235750