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- Title
Penfluridol as a Candidate of Drug Repurposing for Anticancer Agent.
- Authors
Tuan, Nguyen Minh; Lee, Chang Hoon; Miyata, Yasuyoshi
- Abstract
Penfluridol has robust antipsychotic efficacy and is a first-generation diphenylbutylpiperidine. Its effects last for several days after a single oral dose and it can be administered once a week to provide better compliance and symptom control. Recently; strong antitumour effects for penfluridol were discovered in various cancer cell lines; such as breast; pancreatic; glioblastoma; and lung cancer cells via several distinct mechanisms. Therefore; penfluridol has drawn much attention as a potentially novel anti-tumour agent. In addition; the anti-cancer effects of penfluridol have been demonstrated in vivo: results showed slight changes in the volume and weight of organs at doses tested in animals. This paper outlines the potential for penfluridol to be developed as a next-generation anticancer drug.
- Subjects
ANTINEOPLASTIC agents; GLIOBLASTOMA multiforme; LUNG cancer; CANCER cells; CELL lines
- Publication
Molecules, 2019, Vol 24, Issue 20, p3659
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules24203659